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The effect of administration of low and high doses of pyridoxine on the metabolism of lipids and glycosaminoglycans has been studied in rats fed normal and high fat, high cholesterol diets. Low doses of pyridoxine (0'005 mg/100 g body weight) caused increased concentrations of cholesterol and triglycerides in the serum and aorta in animals fed normal and high fat, high cholesterol diets. Administration of high doses of pyridoxine (5'0 mg/100 g body weight) caused decrease in the concentration of these lipids in these tissues except in the case of the aorta in the animals fed a normal diet.

australian journal of biological sciences

Pyridoxine and Atherosclerosis: Role of Pyridoxine in the Metabolism of Lipids and Glycosaminoglycans in Rats Fed Normal and High Fat, High Cholesterol Diets Containing 16 % Casein