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Bronchiolitis obliterans is the greatest limitation to the long-term applicability of lung transplantation. Although alloimmune events are important, nonimmune events, such as gastroesophageal reflux, might contribute to lung injury and the development of bronchiolitis obliterans syndrome.

Improved lung allograft function after fundoplication in patients with gastroesophageal reflux disease undergoing lung transplantation