English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Relative lifetimes of inherent double stranded DNA openings with lengths upto ten base pairs are presented for different gene promoters and correspondingmutants that either increase or decrease transcriptional activity, in theframework of the Peyrard-Bishop-Dauxois model. Extensive microcanonicalsimulations are used, with energies corresponding to physiological temperature.The bubble lifetime profiles along the DNA sequences demonstrate a significantreduction of the average lifetime at the mutation sites when the mutatedpromoter decreases transcription, while a corresponding enhancement of thebubble lifetime is observed in the case of mutations leading to increasedtranscription. The relative difference of bubble lifetimes between the mutatedand the wild type promoters at the position of mutation varies from 20% to morethan 30% as the bubble length is decreasing

Bubble lifetimes in DNA gene promoters and their mutations affecting transcription