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Comprehensive study of generalized baryon-baryon ($BB$) interaction includingstrangeness is one of the important subject of nuclear physics. In order toobtain a complete set of isospin-base baryon interactions, we perform a largescale lattice QCD calculation with almost physical quark masses correspondingto $(m_\pi,m_K)\approx(146,525)$ MeV and large volume $(La)^4=(96a)^4\approx$(8.1 fm)$^4$. A large number of Nambu-Bethe-Salpeter (NBS) correlationfunctions from nucleon-nucleon ($NN$) to $\Xi\Xi$ are calculatedsimultaneously. In this contribution, we focus on the strangeness $S=-1$channels of the hyperon interactions by means of HAL QCD method. Threepotentials ((i) the $^1S_0$ central, (ii) the $^3S_1-^3D_1$ central, and (iii)$^3S_1-^3D_1$ tensor potentials) are presented for four isospin components; (1)the $\Sigma N - \Sigma N$ (the isospin $I=3/2$) diagonal, (2) the $\Lambda N -\Lambda N$ diagonal, (3) the $\Lambda N \rightarrow \Sigma N$ transition, and(4) the $\Sigma N - \Sigma N$ ($I=1/2$) diagonal. Scattering phase shifts for$\Sigma N$ $(I=3/2)$ system are presented.

Hyperon-Nucleon Interaction from Lattice QCD at ${(m_\pi,m_K)\approx(146,525)}$ MeV