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Digital two-dimensional (2D) spatial sampling devices (such as charge-coupleddevice) have been widely used in various imaging systems, especially incomputational imaging systems. However, the undersampling of digital samplingdevices is a problem that limits the resolution of the acquired images. In thisstudy, we present a synthetic sampling imaging (SSI) concept to solve theundersampling problem. It combines the structured illumination system andconventional 2D image detection system to simultaneously sample the specimenfrom the illumination and the detection sides. Then, we synthesize theillumination sampling rate and the detection sampling rate to reconstruct ahigh sampling rate image. The concept of the proposed SSI is demonstrated by anexample of microscopy. Experimental results confirm that the proposed methodcan double the sampling resolution of the microscope. The synthetic samplingscheme, where the sampling task is shared by the illumination and detectionsides, provides insight for resolving the undersampling problem of the digitalimaging system.

Optical synthetic sampling imaging: concept and an example of microscopy