English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Compounds bearing the 1,2,3-thiadiazole ring possess herbicidal, fungicidal and phytohormonal properties [1, 2]. At the same time, it has been found that the 1,2,3-triazole derivatives exhibit antimicrobial, antiviral and antitumoral activities [3]. The aim of the present work was a synthesis of previously undescribed 1,2,3-thiadiazole-1,2,3-triazole hybrid possessing valuable properties of both heterocycles. Acidification of 1,2,3-triazolium-5-olate 1 led to opening of the triazole ring and formation of -diazoacetamide 2. The latter underwent condensation with 1,2,3-thiadiazole-4-carboxylic acid hydrazide 3, affording the corresponding hydrazone 4. Following this, interaction between diazo group and NH hydrazide moiety resulted in cyclization of hydrazone with formation of 1,2,3-triazolyl-carboxamide1,2,3-thiadiazole 5 (Scheme).

Reaction of sodium 4-acetyl-1-phenyl-1H-1,2,3-triazol-5-olate with 1,2,3-thiadiazole-4-carboxylic acid hydrazide