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We explore the feasibility of using fast-slow asymptotic to eliminate thecomputational stiffness of the discrete-state, continuous-time deterministicMarkov chain models of ionic channels underlying cardiac excitability. We focuson a Markov chain model of the fast sodium current, and investigate itsasymptotic behaviour with respect to small parameters identified in differentways.

Fast-slow asymptotics for a Markov chain model of fast sodium current