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Circulating tumor cells (CTCs) are found in the blood of patients with cancer.\udAlthough these cells are rare, they can provide useful information for chemotherapy.\udHowever, isolation of these rare cells from blood is technically challenging because\udthey are small in numbers. An integrated microfluidic chip, dubbed as CTC chip, was\uddesigned and fabricated for conducting tumor cell isolation. As CTCs usually show\udmultidrug resistance (MDR), the effect of MDR inhibitors on chemotherapeutic drug\udaccumulation in the isolated single tumor cell is measured. As a model of CTC\udisolation, human prostate tumor cells were mixed with mouse blood cells and the labelfree\udisolation of the tumor cells was conducted based on cell size difference. The major\udadvantages of the CTC chip are the ability for fast cell isolation, followed by multiple\udrounds of single-cell measurements, suggesting a potential assay for detecting the drug\udresponses based on the liquid biopsy of cancer patients

biomicrofluidics

Label-free isolation of a prostate cancer cell among blood cells and the single-cell measurement of drug accumulation using an integrated microfluidic chip