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Monte Carlo simulations are used to study the translocation of a polymer intoand out of a ellipsoidal cavity through a narrow pore. We measure the polymerfree energy F as a function of a translocation coordinate, s, defined to be thenumber of bonds that have entered the cavity. To study polymer insertion, weconsider the case of a driving force acting on monomers inside the pore, aswell as monomer attraction to the cavity wall. We examine the changes to F(s)upon variation in the shape anisometry and volume of the cavity, the polymerlength, and the strength of the interactions driving the insertion. Forathermal systems, the free energy functions are analyzed using a scalingapproach, where we treat the confined portion of the polymer to be in thesemi-dilute regime. The free energy functions are used with the Fokker-Planckequation to measure mean translocation times, as well as translocation timedistributions. We find that both polymer ejection and insertion is faster forellipsoidal cavities than for spherical cavities. The results are inqualitative agreement with those of a Langevin dynamics study in the case ofejection but not for insertion. The discrepancy is likely due toout-of-equilibrium conformational behaviour that is not accounted for in the FPapproach

Polymer translocation into and out of an ellipsoidal cavity