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Dynamic-mode atomic force microscopy (AFM) in liquid remains complicated dueto the strong viscous damping of the cantilever resonance. Here we show that ahigh-quality resonance (Q>20) can be achieved in aqueous solution by attachinga microgram-bead at the end of the nanogram-cantilever. The resulting increasein cantilever mass causes the resonance frequency to drop significantly.However, the force sensitivity --- as expressed via the minimum detectableforce gradient --- is hardly affected, because of the enhanced quality factor.Via the enhancement of the quality factor, the attached bead also reduces therelative importance of noise in the deflection detector. It can thus yield animproved signal-to-noise ratio when this detector noise is significant. Wedescribe and analyze these effects for a set-up which includes magneticactuation of the cantilevers and which can be easily implemented in any AFMsystem that is compatible with an inverted optical microscope.

Enhanced quality factors and force sensitivity by attaching magnetic beads to cantilevers for atomic force microscopy in liquid