English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The interplay between cytoskeletal architecture and the nonlinearity of theinteractions due to bucklable filaments plays a key role in modulating thecell's mechanical stability and affecting its structural rearrangements. Westudy a model of cytoskeletal structure treating it as an amorphous network ofhard centers rigidly cross-linked by nonlinear elastic strings, neglecting theeffects of motorization. Using simulations along with a self-consistent phononmethod, we show that this minimal model exhibits diverse thermodynamicallystable mechanical phases that depend on excluded volume, crosslinkconcentration, filament length and stiffness. Within the framework set by thefree energy functional formulation and making use of the random first ordertransition theory of structural glasses, we further estimate the characteristicdensities for a kinetic glass transition to occur in this model system. Networkconnectivity strongly modulates the transition boundaries between variousequilibrium phases, as well as the kinetic glass transition density.

The Interplay of Nonlinearity and Architecture in Equilibrium Cytoskeletal Mechanics