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Today many potent anticancer drugs like cisplatin are available which carry a number of side effects. A promising way of reducing the side effects is to target the drug to tissue sites by coating it with biocompatible materials like Poly (dl-lactide-co-glycolide) (PLGA) polymer where controlled drug release is achieved during the biodegradation of the polymer. Also the efficacy of anticancer drugs like cisplatin increases at elevated temperatures, so if local heating can be achieved where the drug is targeted. Local heating can be achieved by introducing iron core nanoparticles in the composites along with the drug, which can be heated by the 2.4 GHz microwaves. Local heating of the nanocomposites also helps to swell the polymer shell and enhance the drug release. The magnetic nanocomposites were synthesized using iron nanoparticles, PLGA and a fluorescent dye, tris-(2,2′bipyridyl) dichlororuthenium (II) using an oil-in-emulsion technique. The emulsion contains PLGA, dye, and iron nanoparticles dissolved ...

Poly(D,L-lactide-co-glycolide) microcomposite containing magnetic iron core nanoparticles as a drug carrier