Rituximab or Cyclosporine in the Treatment of Membranous Nephropathy
Author(s) -
Fernando C. Fervenza,
Gerald B. Appel,
Sean J. Barbour,
Brad H. Rovin,
Richard Lafayette,
Nabeel Aslam,
Jonathan Ashley Jefferson,
Patrick E. Gipson,
Dana V. Rizk,
John R. Sedor,
James F. Simon,
Ellen T. McCarthy,
Paul Brenchley,
Sanjeev Sethi,
Carmen Ávila-Casado,
Heather Beanlands,
John C. Lieske,
David Philibert,
Tingting Li,
Leslie F. Thomas,
Dolly F. Green,
Luis A. Juncos,
Lada BearaLasić,
Samuel S. Blumenthal,
Amy N. Sussman,
Stephen B. Erickson,
Michelle Hladunewich,
Pietro A. Canetta,
Lee A. Hebert,
Nelson Leung,
Jay Radhakrishnan,
Heather N. Reich,
Samir V. Parikh,
Debbie S. Gipson,
Dominic K. Lee,
Bruno R. da Costa,
Peter Jüni,
Daniel Cattran
Publication year - 2019
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa1814427
Subject(s) - rituximab , membranous nephropathy , medicine , immunology , antibody , glomerulonephritis , kidney
B-cell anomalies play a role in the pathogenesis of membranous nephropathy. B-cell depletion with rituximab may therefore be noninferior to treatment with cyclosporine for inducing and maintaining a complete or partial remission of proteinuria in patients with this condition.
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