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The amount of protein leakage from colon cancers is thought to be less than occurs with other colon diseases [1], and cases of protein−losing colon cancer have rarely been reported. We encountered a case of protein−losing colon cancer associated with severe diarrhea and hypoproteine− mia in an 85−year−old woman. Computed tomography showed a large tumor in the ascending colon and massive ascites (Fig− ure 1). Total colonoscopy revealed a giant nodular tumor with a surface that was whitish−yellow in color in the ascending colon (Figure 2). The patient was appar− ently not considered suitable for surgery because of carcinomatosa, but abdominal paracentesis was not suggestive of malig− nancy. We suspected that the hypopro− teinemia was caused by protein leakage from the colonic lesion. The fecal alpha1− antitrypsin clearance was measured and found to be remarkably high at 232 ml/ day (normal ramge < 20 ml/day). Human serum albumin scintigraphy revealed marked albumin leakage from the lesion (Figure 3).

A patient with protein-losing colon cancer with massive ascites who was successfully treated by surgical resection of the tumor