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We report on a 36-year old male patient with a clinically unusual treatment refractory subungual horny verrucous big size exophytic tumor of his third finger. Histology revealed a very thick papillomatory hyperkeratotic epithelial tumor with koilocytes and many atypic cells and mitoses. PCR analysis disclosed presence of HPV type 16 DNA in the tumor. Histological and virologic findings lead to the diagnosis of a warty squamous cell carcinoma. Clinically the lesions resembled a verrucous carcinoma of the epithelioma cuniculatum type. To our knowledge the presented case is the first reported warty carcinoma located at the hand and the first to demonstrate HPV 16 DNA in a warty squamous cell carcinoma or a verrucous carcinoma located at the hand.

HPV 16-positives subunguales „Warty Squamous Cell Carcinoma” (warziges Karzinom) der Hand