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There is a wide variety of therapies for the treatment of mollusca contagiosa. In particular, treatment in young or anxious children is difficult, painful, and often time consuming. We investigated whether imiquimod 5% (1-(2-methylpropyl)-1H-imidazo(4,5-c) quinolin-4 amin), a topical immune response modifier that stimulates the production of interferon-α and other cytokines, is an effective treatment for mollusca contagiosa. In this clinical trial we followed 15 children with multiple mollusca contagiosa, aged 4-11 years, for 16 weeks. The treatment was administered 3 times per week. The overall response rate was 69% (9 children). Out ofthese 2 patients (15%) showed a complete remission and 7 children (54%) had partial response with a remarkable reduction of mollusca contagiosa. 4 children (31 %) showed stable or progressive disease. In three children (23%) with partial remission the large number of mollusca could be considerably reduced; thus surgical treatment in anaesthesia could be avoided. In general, the treatment was well tolerated. Side effects included erythema (85%), itching (75%), burning sensations (23%) and pain (8%). 4 children (31 %) stopped the treatment because of local side-effects. No systemic side effects were observed. The results of this study suggest that imiquimod 5 % is a useful new therapy for the treatment of mollusca contagiosa in children, especially in severe cases. The dosing schedule and length of treatment for mollusca contagiosa require further evaluation.

Eine Pilotstudie zur Wirksamkeit von Imiquimod in der Behandlung von Mollusca contagiosa bei Kindern