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Today knowledge about pharmacokinetics of anticancer drugs in human malignant tumors is poor. Data from in vivo studies are limited and difficult to obtain due to ethical aspects. An ex vivo isolated perfused and ventilated human lung model however allows pharmacological studies of human bronchial carcinoma inside their host organ, the lung, under physiological conditions without compromising the patient.

pneumologie

Pharmakokinetik von Cyclo-phosphamid, Adriamycin und Adramycin-Prodrug (HMR 1826) im ex-vivo-isolierten perfundierten humanen Lungenresektionsmodell (IHLP)1