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A 58-year-old man with severe alcoholrelated necrotizing pancreatitis was admitted and was treated initially with conservative management including aggressive intravenous fluid hydration and placement of a percutaneous gastrojejunostomy tube for enteral nutrition. Endoscopic retrograde cholangiopancreatography (ERCP) was performed with no evidence of pancreatic duct disruption or contrast leakage, but sludge was swept from the bile duct and biliary sphincterotomy was performed. Endoscopic ultrasound (EUS) revealed acute inflammatory changes in the entire pancreas without any well-formed fluid collection that could be drained. The patient was treated conservatively with aggressive intravenous fluid hydration, bowel rest, and enteral nutrition for 4 weeks. He subsequently developed sepsis and a repeat computed tomography (CT) scan was performed, which demonstrated a large, complex 17×7-cm pancreatic fluid collection that was extending from the left anterior perirenal space to the left lower quadrant in the pelvis. EUS-guided cystgastrostomy was performed with a 15-mm lumen-apposing metal stent (LAMS; Axios, Boston Scientific, Natick, Massachusetts, USA). An ultrathin upper gastrointestinal (GI) endoscope was then used to enter the cyst cavity and a necrotic fistula tract was identified that extended into the jejunum with necrosis involving the jejunal lumen. Wire guidance was used to place a bridging esophageal fully covered self-expanding metal stent (FCSEMS; Wallstent, Boston Scientific) across the jejunal fistula tract with the distal end being in the jejunum and the proximal end in the stomach via the LAMS creating a cystgastrojejunostomy (▶Video1). A 12-mm over-thescope clip (OTSC; Ovesco, Cary, North Carolina, USA) was used to anchor the FCSEMS to the gastric mucosa to prevent migration. A repeat CT scan 2 weeks later showed interval improvement in the necrotic fluid collection but a 13×2.7-cm residual collection was seen extending deep into the left pelvis (▶Fig. 1). The decision was made to pursue repeat EUS-guided drainage through the existing cystgastrostomy fistula to access the deep pelvic collection. An upper GI endoscopy was performed with removal of the bridging cystgastrojejunostomy stents. The fistula tract appeared mature. An echoendoscope was then advanced through the fistula tract into the jejunum. The posterior pancreatic fluid collection was identified; a 15-mm LAMS (Axios, Boston Scientific) was deployed using an EUS-guided tech-

Novel management of a necrotic pancreatic fluid collection with staged cystgastrostomy followed by cystgastrojejunostomy: the Lizzie Grace maneuver