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A 55-year-old woman was found to have a depressed lesion on the posterior part of the lower gastric body (▶Fig. 1 a). The patient underwent endoscopic submucosal dissection (ESD) and en bloc resection without intraoperative perforation. Prophylactic endoscopic coagulation using Coagrasper (Olympus Medical, Tokyo, Japan) was performed for visible vessels, and endoclips were applied prophylactically to close tiny injuries to the muscularis propria (▶Fig. 1b). As significant bile juice reflux was noticed during endoscopy, a 14-Fr soft nasogastric tube was inserted. Smooth drainage of gastric fluid was observed. During the night following the procedure, the patient developed severe upper abdominal pain and nausea, and both radiography and computed tomography revealed free air, with a migrated nasogastric tube outside the stomach (▶Fig. 2 a). Emergency esophagogastroduodenoscopy (EGD) after removal of the tube identified a cylindrical perforation, which was probably caused by mechanical penetration of the nasogastric tube (▶Fig. 2 a, b, ▶Video1). After interdisciplinary discussion with surgeons it was decided to close the perforation endoscopically. The whole wall defect was closed using an over-thescope clip (OTSC, 12/6t; Ovesco, Tübingen, Germany). A Twin grasper (Ovesco) was necessary to grasp and appose the two edges of the perforation site. After careful retraction of the edges into the cap, the OTSC device was directed towards the perforation, the clip was released, and the wound was closed successfully (▶Fig. 2 c). Follow-up EGD demonstrated sustained closure of the perforation, and gastric series confirmed no leakage of contrast (▶Fig. 2d, ▶Video1). The patient was discharged home 12 days after ESD. The resected specimen revealed a completely resected, depressed mucosal adenocarcinoma, 18mm in size with moderate to poor differentiation, but without lymphovascular invasion or ulceration. Some experts recommend nasogastric tube intubation for diversion of gastrointestinal fluids such as bile, which may induce delayed perforation after gastric ESD [1, 2]. This case highlights the utility of large size OTSCs with Twin grasper to close a rare but complex delayed perforation, which was probably caused by a post-ESD nasogastric tube. Although endoclips can be used, this perforation was complex and large, and thus it would have been impossible or technically much more challenging to close the hole. The opposition forces of OTSCs are much stronger and may result in a more secure closure, thus avoiding emergency surgery [3, 4].

endoscopy

Successful endoscopic closure using over-the-scope clip for delayed stomach perforation caused by nasogastric tube after endoscopic submucosal dissection