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Amyl nitrite is easily administered and is a potent short-acting smooth muscle relaxant. Therefore, it can be used to relax the lower esophageal sphincter (LES) during submucosal tunneling in peroral endoscopic myotomy (POEM) (●" Fig.1) [1,2]. One study demonstrated that the diameter of the LES increased by >3mm in patients with idiopathic achalasia in response to amyl nitrite [3]. POEM involves the creation of a submucosal tunnel, for which dissection of fibers should be carried out close to the muscle layer to avoid mucosal injury. When the LES is tight, this dissection of the fibers can be challenging to perform safely without risking mucosal injury.●" Video1 demonstrates the use of amyl nitrite inhalation to relax the LES and facilitate submucosal tunneling in two patients. The first patient was a 59-year-old man who underwent POEM for type III achalasia. During tunneling, the distal esophagus and LES were spastic, which inhibited the advancement of the endoscope. The decision was made to use amyl nitrite. During its administration, the patient’s heart rate increased by 10 beats per minute (bpm) from a baseline of 70bpm and his blood pressure (BP) decreased to 95/68mmHg from 117/70mmHg. The second patient was a 38-year-oldwomanwhounderwent POEM for type II achalasia. During POEM her LES was found to be tight, which prevented effective and safe tunneling. When amyl nitrite was given, her heart rate increased by 10bpm from baseline and her systolic BP dropped to 80mmHg from a baseline of 116mmHg. Both patients were admitted to the hospital for observation following their procedures. They were discharged home on soft diet and returned to clinic 4 weeks later with complete resolution of their symptoms. We conclude that amyl nitrite is a safe and effective method to relax the LES. This technique may be utilized in patients where the safe creation of a submucosal tunnel through the LES might otherwise not have been possible.

Novel technique to relax the lower esophageal sphincter during challenging peroral endoscopic myotomy (POEM)