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Despite the agreement that there is no longer any indication for arsenic use in modern endodontics, some concerns are surfacing about the minute amount of arsenic trioxide (As 2 O 3 ) released from Portland cement-based materials. The present study investigated the effect of different concentrations of As 2 O 3 on rat pulpal cells and the efficacy of N -acetylcysteine (NAC) in preventing As 2 O 3 -mediated toxicity.

The Hormetic Effect of Arsenic Trioxide on Rat Pulpal Cells: An In Vitro Preliminary Study