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Objectives: To evaluate the clinical effect of Bacillus coagulanson plaque induced gingivitis.  Method: Thirty subjects with plaque induced were enrolled in the study. At baseline, Gingival Index (GI) and Plaque Index (PI) were assessed. Saliva samples were collected for glutathione peroxidise (GPx) activity analysis and to determine load of lactobacilli. Subsequently participants were randomly provided with chewable tablets to be consumed 3 X daily for 3 month containing 100 million colony forming units (CFU)/tablet of B. coagulans or without B. coagulans (placebo). After3 months, recording of GI, Pl and saliva sampling were repeated.  Results: At baseline, mean GI, and mean Pl did not differ significantly between both groups. At re-evaluation, mean GI, and bleeding on probing of the probiotic group were both significantly (p &lt; 0.0001) lower than in the placebo group. Mean PI level did not differ significantly between the groups. In the probiotic group, mean glutathione peroxide activity (Gpx)was significantly (p &lt; 0.02) lower than in the placebo group at re-evaluation.  Conclusion: The consumption of probiotic containing Bacillus coagulans seems to modulate inflammatory response in plaque induced gingivitis.

Clinical effect of pro-biotic containing Bacillus coagulans on plaque induced gingivitis : A randomised clinical pilot study