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Propofol, being a lipid emulsion, is a good medium for bacterial growth. Adhering to manufacturer's recommendations of “use without delay” is often difficult. This is because of the need to use small quantity of the drug during general anaesthesia, such as to reduce the intubation response, increase the depth of anaesthesia, prevention of extubation response and laryngospasm in addition to induction of anaesthesia. This results in a delay between opening of the vial and using the last portion of the drug. Extrinsic contamination of propofol by various microorganisms has been associated with outbreaks of bloodstream infections, surgical site infections, and acute

Incidence and Pattern of Bacterial Growth in Propofol Vial - An In vitro Study