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γ-linolenic acid, dihomo-γ-linolenic acid and Naudicelle, a naturally-occurring rich source of essential unsaturated fatty acids have been evaluated as potential antithrombotic agents. A sequential series of tests was used to compare each substance in vitro (human plasma), in vivo using an artificially induced thrombus in the microcirculation of small laboratory animals and ex vivo in non-human primates with a spontaneous pathological thrombotic tendency. Finally the test substances were compared in man after oral administration. Particular reference was made to the effects of the compounds on platelet function, the fibrinolytic system, thrombus formation and on circulating blood lipids. The compounds which are possible prostaglandin precursors, have been shown to have a positive (antithrombotic) effect in the test systems used. Platelet aggregation was inhibited over 24 hours in non-human primates and in man at oral dose levels of 1.5 mg/kg. In addition plasma cholesterol and triglycerides were decreased by up to 50% on the same dose regime.

thrombosis and haemostasis

The Comparative Evaluation of γ-Linolenic Acid and Dihomo-γ-Linolenic Acid, their Esters and Possible Precursors as Potential Antithrombotic/Thrombolytic Agents