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A method is described for continuous, long term, ambulatory, out-patient, intravenous heparin therapy in human subjects. A portable light-weight pump originally designed for ambulatory, continuous intravascular chemotherapy in patients with malignant neoplastic disease was employed for this purpose. Six studies in four patients have been conducted to date. Diagnoses included: carcinoma of the breast, 65 year old female, thrombophlebitis of the iliofemoral veins and inferior vena cava thrombosis; carcinoma of the tonsil, 49 year old female, pulmonary emboli; carcinoma of the lung, 51 year old male; carcinoma of the lung, 47 year old female. In one patient, three individual courses of therapy were conducted for 56, 105 and 111 days. In the remainder, intravenous therapy was continuous for 58, 39 and 26 days respectively. The anticoagulant effect was almost continuously optimal and free of unusual, bleeding. There have been no adverse effects from the use of heparin in this fashion. Infection did not occur at the site of insertion of the intravenous catheter. The method is recommended for trial in selected patients with recurrent thrombotic disease and for experimental therapy in patients with malignant neoplastic disease where a trial of such adjuvant therapy may be indicated and feasible, on an ambulatory, out-patient basis.

Heparin Therapy in Ambulatory, Out-Patient Human Subjects by Continuous, Long Term, Intravenous Infusion Employing a Portable Pump