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In 80 Norwegian families with severe hemophilia A (f.VIII ≤1%) 119 living cases are under study. In 40 of these families only one hemophiliac is known, and in 2 families only 2 hemophilic brothers; investigations showed that of 38 of the mothers 30 were carriers, 8 not carriers or uncertain. In 7 of the 42 families, 9 cases of leukemia, most of them myeloid type, were recorded, and one case of myelomatosis. In 6 of these families low blood f.XII, about half of normal average activity, was demonstrated in the hemophiliac and/or in his mother and/or in one of her parents. Informations from Norwegian families with non-isolated severe hemophilia A, have given no records of leukemia. The high incidence of leukemia in families with isolated cases of severe hemophilia A indicates a common predisposing cause to leukemia and to mutations to hemophilia A.

Leukemia in Families with Isolated Cases of Severe Hemophilia A.