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In some diseases, particularly in diseases of the vessels, there is a spontaneous aggregation of platelets. So it was of interest, whether in patients with diseases of the kidneys and essential hypertension there is a frequent spontaneous aggregation as well. In addition, the effect of the antithrombotic substance sulfinpyrazone on platelet aggregation, on plasmatic coagulation and on clinical parameters, for instance on proteinuria, was to be investigated. In 47 patients with diseases of the kidneys or essential hypertension spontaneous platelet aggregation, thrombin time, partial thromboplastin time, fibrinogen and factor VIII were studied. Patients with spontaneous platelet aggregation were given 800 mg sulfinpyrazone daily for I to 6 months. In 15 of 16 patients with chronic glomerulonephritis (serum creatinine 0,7-2,0 mg%) and 13 of 14 patients with a chronic pyelonephritis (serum creatinine 0,8–1,7 mg%) spontaneous platelet aggregation was found as well. So in almost all patients with chronic glomerulonephritis and pyelonephritis a spontaneous aggregation was seen. The frequency of spontaneous platelet aggregation in patients with essential hypertension is likely to depend on the stage of hypertension. Spontaneous platelet aggregation did not return to normal in any of our patients on sulfinpyrazone and the substance had no influence on proteinuria, haematuria and leukocyturia in patients with diseases of the kidneys.

Spontaneous Platelet Aggregation and Sulfinpyrazone Influence in Patients with Diseases of the Kidneys and Hypertension