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To predict thrombosis and to evaluate anti-thrombotic agents, a thrombokinetic study was done on subjects in thrombogenic state with cardio-vascular and hematologic diseases, artificial heart valve replacement, thromboangiitis and thrombocythemia. Platelets were labelled with 51Cr (Thromb. Res. 8, Suppl. 11: 347, 1976).During thrombocytosis (&gt;106/mm3), 2 of 4 cases with primary thrombocythemia and 3 of 4 cases of chronic myelogenous leukemia (2 of whom developed thrombosis) had shortened survival. This increased turnover reflected compensatory production of platelets and increased thrombopoiesis. Fourteen cases with artificial heart valve replacement showed short survival with proportionally higher turnover. Three cases with short survival despite high doses of dipyridamole therapy developed thrombosis.  To evaluate platelet participation in the development of cerebrovascular lesion; cerebral infarction and/or bleeding in animal model, platelet survivals were measured by 75se-methionine incorporation in the spontaneously hypertensive rat-stroke prone strain, (SHR-SP, Okamoto-Yamori), which become hypertensive at age 5-25 weeks. Peak of 75se-methionine in platelets which develop hypertension at age, 5-25 weeks occur on 3rd. day after I.V. injection in SHR-SP and controls (SHR-stroke resistant and normotensive Wistar rat), and was significantly higher in SHR-SP than the controls. Survivals by 75se-methionine and by 51cr labels (16th Int. Congr. Hemat. Sept. 1976, Kyoto, Abstr. Symp. S-12-4, pp. 39) suggested shorter survival of SHR-SP in 10-15 weeks of age than control. Short survival with increased turnover indicated increased consumption due possibly to vascular damage associated with the development of hypertension. Ability to predict strokes in adult rats has been examined.

Thrombokinetic Study to Predict Episodes of Thrombogenesis