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Few, if any studies of coagulation and fibrinolysis have been performed in Asian women. This was because they seemed to be immune from thromboembolic diseases. Since it has been confirmed that the risk of thromboembolism in Caucasian women on oral contraceptives containing 50 microgram of oestrogen is much increased, and that there are also coagulation changes in them, it was found therefore necessary to do similar studies in Asian women.  The present report is a prospective study of 100 women on the combined pill containing not less than 50 ug oestrogen. A comprehensive number of tests were performed for the overall clotting effect, coagulation factors and inhibitors, fibrinolysis and inhibitors, and platelet function tests.  The overall clotting time seemed to be reduced. Certain coagulation factors were elevated, especially factor VII and factor X. Antithrombin III levels remained the same. There were no significant fibrinolytic changes in the blood. Platelet function tests were not significantly changed. The changes in the blood profile although similar to Caucasian women, have still to be evaluated in its significance to the risk of developing thromboembolic disease.

Coagulation Studies in Asian Women on the 50 Microgram Combined Oral Contraceptive Pill