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On the basis of a new test for counting circulating endothelial cells in blood, a group of drugs was redefined which prevent endothelial desquamation after a standard intravenous injection of citrate into rats. The group comprised practically all drugs designated as venotonics or vitamin P-active agents, including some haemostatics, analgesic-antipyretics (acetylsalicylic acid) and some antiatherosclerotics (pyridinolcarbamate, Clofibrate). A marked activity was observed also with several calcium-antagonists (nifedipine, prenylamine, chromonar, dipyridamole and verapamil). Many endothelotropic drugs are simultaneously effective in blocking platelet functions. The suggested common mechanism of action is the influence on the consistency of the cellular surface coat (endothelia cement).

Endothelotropic Drugs - Stabilizers of the Endothelial Lining Against Desquamation