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We investigated the efficacy of detecting fresh pulmonary emboli in dogs using 2 different age preparations of Indium-111 autologous platelets. Clots were induced in jugular veins of 18 mongrel dogs weighing 12-26 kg by ligating a segment of the jugular vein and the addition of thrombin. Clots thus formed were left in situ for 24 hours and then released into the pulmonary circulation. Pulmonary angiography (PA) was performed immediately before and after embolization. Scintillation imaging (SI) of the lungs was performed with a high resolution LFOV camera within 4 hours of embolization. There were 28 autopsy-iden tified clots in the lungs, of which 26 (92%:26/28) were detected by PA. Of these, SI detected 14. SI also detected 2 additional clots missed by PA.  Using PA as standard, the overall detection rate of SI was 54% (14/26). There was some difference between platelets of 4 hours (69%:9/13) and those labeled 24 hours before (38%:5/13). The difference was not significant. As expected, SI detectability was related to the product of concentration ratios between clot and blood (C/B) and weight (Wt) of the clots and not to either one alone: Data showed that Indium-111 platelets appeared to be a promising radiopharmaceutical for the detection of throm- boemboli and that the freshly prepared platelets should be preferred.

Indium-111 Autologous Platelets In The Detection Of Experimental Pulmonary Emboli