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Survival time of Na51Cr-label led platelets was measured in rabbits and results calculated by linear regression. In 10 normal rabbits, survival was 81.9 ± 3-3 hours (mean ±SEM). This was not significantly different at 85.2 ± 4.6 hours in 8 rabbits in which survival was repeated following trauma to the aorta by single passage of an inflated balloon catheter. Indwelling nylon cannulae (4FG) were inserted through the femoral artery to lie the full-length of the aorta. Platelet survival was significantly (p&lt;0.01) shortened from 79.7 ± 3.7 hours in 9 shamoperated animals to 62.2 ± 2.4 hours in 10 cannulated rabbits. Administration of the thromboxane synthetase inhibitor UK37248 at 10mg/kg in two oral doses daily did not prolong platelet survival (64.5 ± 3.4 hours, n = 14). Measurement of serum T×B2 concentration in samples taken at random indicated inhibition ranging from 10 to 95% during the five days of study. Incomplete inhibition of thromboxane synthetase might account for the lack of effect. However treatment of 4 cannulated rabbits with sulphinpyra- zone 20mg/kg/day also failed to prolong platelet survival (53.9 ± 3.0 hours). The results suggest that this model of platelet survival may prove resistent to the effects of anti-platelet drugs.

Platelet Survival In Rabbits Treated With Uk37248 Or With Sulphinpyrazone