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In view of earlier investigations which had revealed that Ticlopidin interferes with fatty acids, the authors decided to study the adsorption and penetration of the molecule on the platelet membrane, as well as its influence on the “membrane microviscosity” of the platelet membrane.  The study was carried out using two different techniques:- study of the adsorption-penetration and/or desorption kinetic by means of a molecule labeled 14C- study of membrane microviscosity by fluoresence polarization measurement (anisotropy of light emission) after incorporating a fluorescent molecule (1.6 diphenyl-1,3,5 hexatriene - DHP)  The measurements were carried out on normal platelet suspensions in a physiological salt medium (I = 0.145 M).  The results reveal:- very rapid fixation of the molecule, whatever the quantities involved (&lt;10mins)- absence of saturation of the adsorption sites, even at very high concentrations (&gt; 400γ/ml).- a very low reversibility of the fixation bond (approx. 25 %) estimated by elution and by elution competition.- a decrease (15 %) in membrane microviscosity for concentrations superior to 200 γ/ml (membrane microviscosity usually increases during platelet activation due to aggregating agents).  On the basis of these results the authors suggest that a physico-chemical mechanism of adsorption-penetration both in an on the platelet membrane might explain some of the biochemical and pharmacological effects observed

Study Of A Membrane Physico-Chemical Mechanism Of The Platelet Anti-Aggregating Effect Of TicloPidin