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30 healthy individuals received single doses of 250,500 or 1000 mg ASA (Aspirin), 10 persons took 750 mg of an ASA preparation with retarded intestinal absorption.24 volunteers received 75 or 150 mg dipyridamole alone or together with 500 mg ASA.  Spontaneous and tissue extract induced platelet stimulation were investigated using interference contrast microscopy. Collagen induced aggregation (1µg/mlPRP) was measured 30 - 45 minutes after blood sampling. Platelet retention was investigated using a modified Hellem test.  Platelet stimulation and retention were inhibited for 8 - 10 hours after the intake of ASA. The higher doses had a more pronounced and longer lasting effect. The effect of 750 mg of the slowly absorbed form of ASA lasted longer than that of 1000 mg Aspirin. Platelet retention was inhibited in a similar way as platelet stimulation. No correlation between the long lasting inhibition of platelet aggregation and the shortlasting effects of ASA on platelet retention and platelet stimulation was found.  It has to be established to which extent the shortlasting effects of ASA and Dipyridamole are essential for the antithrombotic effect of both drugs. If these effects are contributing to the antithrombotic effect of ASA, differences in the results of similar clinical trials as the AMIS and PARIS studies on patients with recent myocardial infarction could be explained by different dose regimens in these studies, e.g.the use of 2 × 500 against 3 × 330 mg ASA.

thrombosis and haemostasis

Shortlasting Effects Of Acetylsalicylic Acid (ASA) And Dipyridamole On Spontaneous And Tissue Extract Induced Platelet Stimulation And On Platelet Retention