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An increased content in sialic acid in the carbohydrate moiety of fibrinogen (fibrinogen sialic acid, FSA) as described in a number of different liver patients has been accounted for the polymerization defect often found in conditions of liver damage.  In 22 cases of liver cirrhosis divided into “moderate” (n = 11) and “severe” (n = 11) according to standardized criteria, FSA was measured with the method of Warren after purification of fibrinogen with β-alanine and glycine, and expressed in mg per 100 mg of fibrinogen.  In the whole group of cirrhotics FSA was 0.79 mg ± 0.17 (controls n = 10, FSA 0.70 mg ± 0.13, p &gt; 0.05). However, FSA was markedly increased in “severe” cases (0.90 mg ± 0.16) both vs controls (p &lt; 0.001) and vs “moderate” cases (0.69 mg ± 0.10, p &lt; 0.005). Thrombin time (TT) although prolonged in cirrhotics (p &lt; 0.001) was not significantly different between the subgroups. FSA correlated inversely with fibrinogen level (p &lt; 0.01) but did not correlate with TT.  These results show that the increase in FSA is a feature of severe liver cirrhosis especially in presence of a low fibrinogen level. Although probably involved in the polymerization defect, this increase alone cannot properly explain the prolongation of TT which is known to occur also in absence of serum FDP.

Fibrinogen In Liver Cirrhosis. Sialic Acid Content Of Fibrinogen In Moderate And Severe Cirrhosis And Relation To Thrombin Time