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We present a lyophilised human plasma which is optimal for calibration curves and factor control in extrinsic as well as in intrinsic system. Comparative assays were carried out between factor control plasma and a fresh plasma pool which was frozen at -70°C from 15 normal young men. The fresh plasma pool and the factor control plasmas for the calibration curves were diluted with Owren’s veronal buffer pH 7,35 in a geometric sequence. All deficiency plasmas (American Dade, Division of American Hospital Supply Corporation) were used according to the instructions of the manufacturer. All assays were carried out by two independant investigators.  For the extrinsic system Thromboplastin C and FS (American Dade) were used. With this thromboplastin the callibration curves for the fresh plasma pool and the factor control plasma showed an identical course when plotted semilogarithmically. The calibration curves for the factors II, V, VII, and X showed a good correlation to normal plasma pool.  For the intrinsic system the PTT-reagent Actin (American Dade) was used. The measuring times for the calibration curves of the factor control plasma are slightly longer than of the fresh plasma pool.  When factors determined in factor control plasmas are read from the fresh plasma calibration curves, the range of normal values is from 90 to 105% for the factors in extrinsic system and from 80 to 105% in intrinsic system. According to these assessments, the factor control plasma seems to be appropriate for establishing calibration curves for factor assays as well as for calibration of thromboplastin time. This is a contribution to further standardization of coagulation assays.

A New Factor Control Plasma For Establishing Calibration Curves For Factor-Assay In Extrinsic And Intrinsic System