English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Chromatography on Sephadex G-200 of the prothrombin complex concentrate, prothrombinex (Px) showed it to have inhibitor and potentiator fractions when tested by the non-activated partial thromboplastin time (NAPTT). The inhibitory effect was related to the heparin content of Px, as it was removed on ECTEOLA-cellulose. The potentiator fraction clotted fibrinogen and this could be inhibited by hirudin. Thrombin-like activity of this fraction was shown using chromogenic substrates. The effect of the potentiator fraction in the NAPTT was markedly enhanced by platelets. Diluted Px and the potentiator fractions caused aggregation of washed platelets which could be inhibited by hirudin. Aggregation was independent of the prostaglandin pathway, as it occurred in washed aspirin-treated platelets. Neither diluted Px nor potentiator fractions aggregated platelets in platelet rich plasma. Infusion of Px was followed by a rise in β-thromboglobulin (β-TG) in 2 of 3 patients two minutes after infusion. This rise could not be ascribed to the presence of β-TG in Px or to the heparin present in Px. These findings suggest that Px has a thrombin-like activity and that its mode of action in patients with factor VIII antibodies may result from its effect on platelets and their interaction with coagulation enzymes.

Effect Of A Non-Activated Prothrombin Complex Concentrate (Prothrombinex) On Platelets: In Vitro And In Vivo Studies