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A 13 year old male patient suffering from an inborn factor XIII deficiency was treated by a factor XIII concentrate to cure a pseudotumor at the leg. Under treatment the patient showed clinical symptoms which were regarded as notyet observed hormonal side effects. The used preparation was made of human placenta. It seemed to be instructive to analyse in this concentrate the amount of several placental hormons.  Three randomised charges of this factor XIII preparation were investigated for the hormonic activity of LH, prolactin, FSH, cortisol, HPL, free oestriol, total oestriol and testosteron. All determinations were carried out by RIA. Elevated concentrations for testosteron and up to the reach of the second period of pregnancy for LH and total oestriol were found.  It is necessary to pay attention to hormonal side effects in treating patients with factor XIII preparations made of placental origin.

Concentrations Of Several Hormons In A Factor XIII Preparation Of Placental Origin