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Antibodies to urokinase have been shown to quench part of the fibrinolytic activity of plasma, not involving the extrinsic system. Previously, the intrinsic system has been subdivided into two parts, one dependent and another independent of factor XII, for activation. Both represent approximately 50 BAU activator activity/ml plasma. The aim of this study was to further locate the UK-related activity within the intrinsic fibrinolytic pathways and to delineate its participation in fibrinolysis tests in vitro.  Antibodies to UK (AUK) were shown not to quench activities of contact factors such as factor XII, prekallikrein and factor XI in coagulation and chromogenic substrate assays. AUK inhibited in normal plasma, Hageman trait and Fletcher trait plasma a discrete portion of approximately 50 BAU activator activity/ml, apparently the activator activity derived from the factor XII-independent system.  Immunoadsorption of plasma with immobilized AUK resulted in a depletion of approximately 50 BAU activator activity/- ml. The contact factors were undisturbed, as were plasminogen and the extrinsic activator. Additions of UK did not restore lost activity, suggesting that AUK has removed the proactivator component.  The amount of UK-related activator activity compares to approximately 0.4 IU urokinase activity/ml, and shows a fairly constant level in individuals and is not enhanced by known stimuli for extrinsic activator release.  Significant contributions to blood fibrinolytic activity in current assay systems, including the dilute blood clot lysis time method could be demonstrated.

The Factor XII-Independent Plasminogen Proactivator System Of Plasma Includes Urokinase-Related Activity