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A new, rapid degradation method for predicting the stability of lyophilised extracts of tissue thromboplastin by accelerated oxygenation is described. This requires less time to complete and is more relevant to tissue thromboplastin age degradation than heat-accelerated methods previously advocated. Lipid oxidation is an important contributor to age-related change of thromboplastins. Although high teinperatures employed in heat degradation may increase oxidative processes in thromboplastin lipids, the protein component essential for procoagulant activity is also denatured.  The practical application of the rapid oxygenation method as a technique for accelerated degradation of tissue thromboplastin reference preparations is described.

Prediction Of Stability Of Thromboplastin