English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

In the mature onset Diabetes Mellitus (DM) high levels of Factor VIII antigen (FVIII R: AG) were reported (Bensoussan et al., 1975, Diabetologia 11, 307; Lufkin et al., 1979, Metabolism 28, 63). The elevated FVIII R: AG levels observed in DM, as well as in other vascular diseases, were claimed as an index of endothelium damage (Boneu et al., 1975, Lancet 1, 1430; Corda et al., 1979, Thrombos. Res. 14, 805). Moreover, since the FVIII R:AG is involved in platelet adhesion to s b- endothelium, its increase might have prognostic significance as thrombogenic risk factor. But, in DM plasma FVIII R: AG levels could be also within normal range, so that the significance as index of endothelial suffering in such evenience would be lacked. Here we report evidence that in DM without clinical signs of vasculopathy, even if the FVIII R: AG plasma levels are in the normal range, the existence of endothelial suffering could be likewise detectable by the simple ve nostasis test, which, notoriously, represents a damaging endothelium stimulus. To test such a possibility we investigated the behaviour of plasma FVIII R: AG levels after venostasis (performed at forearm pressure of 10 mmHg over diastolic × 20 min) in 12 diabetic patients without overt signs of vasculopathy and exhibiting FVIII R: AG in normal range. This group was matched with 10 normal subjects of comparable sex and age. Measurements of the serum LDH levels before and after venostasis served to prove cellular damage when they increased more than 50%. The diabetic patients showed after venostasis an increase of FVIII R: AG (Laurell’s method)which was significantly higher than normal controls (P&lt;0.005). Therefore it might be assumed that in diabetic subjects a latent vascular endothelium suffering, even without overt signs of vasculopathy, could exist and it could be detectable by venostasis test.

Factor VIII Antigen And Venostasis Test In Diabetes Mellitus. A Possible Useful Tool To Detect A Latent Endothelial Suffering