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Two patients with acquired von Willebrand’s disease were given an infusion of 2000 units of high purity porcine factor VIII (Hyate) which we previously have shown contains only negligible amounts of FVIIIR: Ag. The disappearance of half life of FVIII:C was 2 hours and 3½ hours. In one patient a marked secondary rise in FVIIIC occurred 1 hour after completion of the infusion. In both patients ristocetin-induced platelet aggregation rose from zero to 10 per cent and 70 per cent respectively between the first and second hour with accompanying rise in human FVIIIR:Ag measured by specific non-crossreacting immuno-radiometric assays. These observations suggest that porcine FVIII:C induced de novo synthesis or release of human FVIIIR:Ag. However an alternative ejqplanation would be dissociation of a FVIIIR:Ag-antibody complex since we have demonstrated antibody directed against the Factor VIII complex in these and other patients with acquired von Willebrand’s disease.

The Factor VIII Response To High Purity Porcine Factor VIII Concentrate In Acquired Von Willebrand’s Disease