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Twenty-one patients affected by mild and moderate Hemophilia A as well as 9 patients with the classic form of vonWillebrand’s disease (vWD) were given a total of 58 infusions of DDAVP. Concerning Hemophilia a three fold mean raise ( x = 3.0, sem O. 19; range of ratios post/preinfusion 1.35 - 5.55) of factor VIII : C levels was observed after the infusion of 0.3 μg/Kg b.w. A mean raise of 3.44 ( sem 0.48, range 2.20 - 6.7) after the infusion of 0.4/ug/Kg was found. The difference between the two regimens is not statistically significant (p &lt; 0.5). As to the vWD 18 infusions were given. In 6 patients the changes of factor VI1I: C, VIIIR: Ag and VIII: vWF were roughly consensual ( ratios post/preinfusion ranging from 2.2 to 4.0 for VIII: C; from 1.8 to 3.5 for VIHR:Ag and from 3.1 to 6.2 for VIII: vWF). In the remaining 3 patients a very strong response of VIII : C ( ratios post/preinfusion 12.0, 15.1 and 6.5) was observed. Also the other properties related to factor VIII underwent to relevant increase. In one of these patients a modified electrophoretic mobility of factor VIII was found; the other two (father and doughter) had a normal factor VIII mobility after stimulation with DDAVP.

Study On The Effect Of Ddavp On Factor VIII- Related Properties In Hemophilia And VWD