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The introduction of chromogenic substrates allowed the development of automated spectophotometric assays. After having developed such methods employing an automated kinetic enzyme and substrate analyser for coagulation factors II and X, antithrombin III (AT III), plasminogen (PG) and α2- antiplasmin (α2-AP) , we decided to apply these methods in well defined clinical projects in order to evaluate their future clinical potency. Results obtained thusfar revealed that 1. AT III and PG are predictors of gram negative septicaemia in patients with intraabdominal infection following major abdominal and vascular surgery, 2. The predictive value of AT III for gram negative septicaemia in prospective studies in premature neonates (all assays require only 0.4 ml of venous blood), 3. AT III remains unchanged in normal pregnancy. Decreasing values are observed in toxaemia and isolated deficiencies are observed as an early sign of intravascular coagulation in pre- ecclampsia, 4. Routine screening of AT III in female subjects on oral anticonceptive drugs is of no use, 5. Factor X assays may possibly be used for the control of oral anticoagulant therapy, 6. Screening of patients with postoperative bleeding disorders may disclose congenital factor X deficiency not reflected by routine prothrombin time measurements.

Clinical Information From Screening Programs For Coagulation And Fibrinolytic Factors And Inhibitor Deficiencies Using Automated Chromogenic Methods