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A highly sensitive enzyme linked immunosorbent assay (ELISA) technique was developed for serological detection of antibodies against platelets. Protein A covalently bound to Sepharose CL-4B was used to enrich sera in the IgG3 subclass. The assay uti lized antigen-coated polystyrene microplates; antigen consisted of sonicated platelets obtained from 0, Rh negative donors. Goat anti-human IgG peroxidase conjugate was used to detect antigen bound antiplatelet antibodies. The ELISA procedure was applied to detect antiplatelet antibodies in patients with herpes or rubella viral infections and in patients with idiopathic thrombocytopenic purpura (ITP). Twenty-eight sera from 13 thrombocytopenic patients showed high levels of antiplatelet antibodies. Two splenectomized patients in remission became negative for antiplatelet antibodies.  Seventy-four sera from patients with serological diagnosis of herpes group viral infections comprising 10 cases of cytomegalovirus, 9 cases of varicella, 6 cases of herpes simplex and 4 cases of Epste in-Barr virus were examined for the presence of antiplatelet antibodies. All ten patients with acute CMV infection presented high titers against platelets. In four of them the highest titer of antiplatelet antibodies was observed even when the specific anti-CMV titer was still very low. All six patients with herpes simplex and all four cases with EBV as well as seven out of nine patients with varicella showed positive titers of antiplatelet antibodies. Out of eight cases of rubella which were also examined seven displayed antibodies against platelets. Sera from a group of 51 healthy controls were evaluated for antiplatelet antibodies. Forty-nine (96%) were negative ( 40), whereas the other two were only slightly positive.

thrombosis and haemostasis

Detection Of Antiplatelet Antibodies In Bstients With Idiopathic Thrombocytopenia Purpura (ITP) And In Patients With Rubella And Herpes Group Viral Infections