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Oral contraceptive (OC) treatment is associated with an increased thrcmbotic risk, the mechanism of which remains still unclear. We have investigated the platelet response to exogenous AA and the plasma and platelet lipid composition in eight healthy women (aged 18-29 y) before and after six month OC treatment with a canbination of d-norgestrel (0.25 mg) and ethynilestradiol (0.05 mg). The threshold aggregating concentration of AA was significantly reduced in platelets of women after 6 months of OC treatment (0.30±0.04 mM versus 0.65 ± 0.08 mM, p &lt; 0.001) whereas it was unchanged in a group of 10 control women, matched for age with the OC treated group and tested twice, with a 6-month interval (0.48 ± 0.04 versus 0.50 ± 0.04). In the same group of patients, seme clotting and fibrinolytic parameters, namely the Normotest, the biological and antigenic activity of Antithranbin III, the anti factor Xa biological activity, the diluted whole blood clot lysis time, were completely unmodified by OC treatment.  In platelets AA increased both in phospholipid and neutral lipid fractions. In plasma the pool of polyunsaturated fatty acids increased at the expense of the saturated pool. In particular, AA increased slightly but significantly in free-fatty acids and phospholipid fractions.  This data indicates that during OC treatment changes in in vitro platelet aggregatory responses may be associated with modifications of platelet and plasma fatty acid composition. Such changes may contribute to the thrcmbotic tendency associated with OC treatment.

Hypersensitivity To Exogenous Arachidonic Acid (Aa) And Redistribution Of Fatty Acids In Platelets From Women On The Pill