English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Patients with the adult respiratory distress syndrome after trauma (the delayed microembolism syndrome) show fibrin deposition in the lungs and delayed elimination of this fibrin. This delayed elimination of fibrin has been supposed to play a key role in the pathogenesis of this syndrome.  In the present investigation we have studied the effect of treatment with purified α2-antiplasmin on the elimination of fibrin from the lungs in rats with thrombin-induced intravascular coagulation. The amount of α2-antiplasmin injected was chosen as to simulate the posttraumatic increase of this inhibitor in man.  Methods. Labelled fibrinogen was injected into a tail vein 24 hours before the experiment. Human α2-antiplasmin, 1.2 mg corresponding to the normal amount in about 12 ml human plasma, dissolved in 1 ml saline was injected into a tail vein 3 minutes before the thrombin injection. Thrombin, 350 NIH units/kg was injected during 5 minutes into a tail vein. The rats were killed 5 or 35 minutes after the end of the thrombin injection and the amount of fibrin in the lungs was determined.  Results. Rats not given α2-antiplasmin showed heavy fibrin deposits determined from radioactive incorporation in the lungs 5 minutes after the thrombin injection. Thirty-five minutes after the thrombin injection most of the fibrin had disappeared from the lungs. Rats given α2-antiplas-min showed the same amount of fibrin in the lungs 5 minutes after the thrombin injection whereas the fibrin amount in the lungs 35 minutes after the thrombin injection was not significantly reduced.  The results may argue for the increase of α2-antiplasmin being of importance for the delayed elimination of fibrin seen in patients in the posttraumatic phase.

Delayed Elimination Of Fibrin From The Lungs In Rats Treated With The Primary Fibrinolysis Inhibitor α2-Antiplasmin