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It has been found that lymphokines can induce thrombocyte aggregation and biood coagulation.  The present study investigated the development of occlusive arterial thrombosis (OAT) in both male and female Wistar rats with altered immunologic background in order to elucidate the immunologic mechanisms in the pathogenesis of OAT.  At the age of 10 weeks neonatally thymectomized rats and sham operated litter mate controls were sensitized with 500g of bovine serum albumin (BSA), injected with complete Freund’s adjuvant in a single hind footpad and a second control sham operated rats were injected only with saline. All animals were skin-tested with 30^g of BSA in saline at 7 and 14 days. Arthus reactions were read 3 to 4 hr. Both the average diameter in millimeters and thickness were recorded. Only reactions eaual and greater than 7 mm in diameter were regarded as positive.  Experimental OAT was induced when rats reached 3 months of age using a polyethylene loop inserted in the abdominal aorta. The mortality rate (MR), dry thrombus weigt (TW) and loop obstruction time (OT) served as criteria for asessment of thrombosis. According to all the criteria used there was a statistical!v significant sun- nression of the development of occlusive arterial thrombosis in the the neonatally tbvmectomized rats of either sex. The oreviouslv observed sex diferense in OAT was more pronounced.  The data presented suggested an involvement of immunologic mechanisms in the thrombogenesis in the arteries and that suitable inhibitors of the immune responses could prove to be of therapeutic value.

Suppressive Effect Of Neoratal Thymectomy On Occlusive Arterial Thrombosis In Sensitized Rats