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Brown pigments from cured tobacco leaf, cigarette smoke condensates and saline extracts of smoke have been referred to as tobacco glycoprotein (TGP) and have been reported to produce allergic skin reactions, induce the formation of IgE antibodies, and to activate clotting factor XII and subsequently activate the fibrinolytic and complement system. These sequential pathological events have been claimed to represent the pathophysiological link between cigarette smoking and cardiopulmonary disease which is observed statisl- tically. To more carefully investigate these claims TGP was extracted by the previously published method of Becker et. al. (Proc. Natl. Acad. Sci. 73:1712-1716, 1976) and the resultant material subjected to in vitro assays related to the claimed biological activities of TGP. It was found that TGP cannot be isolated following the above procedure; the final product obtained by the isolation procedure contains a contaminant introduced by PAGE separation. The contaminant (CMT) appears to be a linear polyacrylate. When this isolated material was subjected to clotting system assays it was found to complex with factor XII, depleting about 15% of factor XII from plasma and,thus, giving the superficial appearance of activating factor XII however, no such activation occurred as noted by non-shortening of the non-activated PTT system, and coagulation factor assays. CMT was found to have no activity on the complement, fibrinolytic, or kinin system. Acrylates are known allergens and thrombus-inducing agents, and these studies suggest that CMT, instead of TGP, has been isolated from cigarette derivitives by the above reported method and CMT rather than TGP has many of the biological activities previously, and perhaps mistakenly, ascribed to TGP.

Studies Related To Tobacco Glycoprotein: A Claimed Activator Of Coagulation, Fibrinolysis, Complement, Kinin, And A Claimed Allergen