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We have previously shown in rabbits that treatment with aspirin (ASA) in doses that inhibit PGI2 production by the aorta does not cause platelet accumulation on the endothelium or cause increased accumulation on the subendothelium when the endothelium has been removed with a balloon catheter. We have also shown that, in contrast to the single layer of platelets that adheres to the subendothelium, extensive microthrombus formation occurs on the surface of the injured neointima. The objective of the present experiments was to compare the effects of ASA and heparin on platelet accumulation on the injured neointima. The endothelium was removed from rabbit aortae with a balloon catheter and at 7 days, when a substantial neointima had formed and was essentially non-reactive to the circulating platelets, the aortae were again injured by the passage of a balloon catheter. Platelet accumulation (measured with 53-Cr- labeled platelets) was approx. 50,000 per mm2 whereas on the uninjured neointima at 7 days it was 1,200 per mm2. Administration of ASA (in a dose that inhibits platelet function and PGI2 production by normal vessels, 100 mg/kg I.V.) 10 min before the neointima was injured did not cause a significant increase or decrease in the number of platelets that accumulated on the injured neointima (53,200 ± 11,200 platelets per mm2 without ASA; 48,100 ± 7,900 platelets per mm2 for ASA-treated rabbits). In contrast to the effects of ASA, heparin (500 U/kg), as described previously, caused a significant reduction in the number of platelets that accumulated on the injured neointima (50,000 ± 8,800 platelets per mm2 without heparin; 25,400 ± 5,500 platelets per mm2 for heparin-treated animals (p&lt;0.05). The results from these experiments indicate that ASA inhibition of platelet function and PGI2 production by the vessel wall does not change platelet accumulation that occurs upon injury of the neointima of a large artery. However, the results with heparin indicate that heparin changes the extent of platelet accumulation on the injured neointima.

Comparison Of The Effects Of Aspirin And Heparin On Platelet Accumulation On The Injured Neointima Of Rabbit Aortae